MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE

Authors
CHUNG YL WILLIAMS A BEECH JS WILLIAMS SCR BELL JD COX IJ HOPE J
Citation
Yl. Chung et al., MRI ASSESSMENT OF THE BLOOD-BRAIN-BARRIER IN A HAMSTER MODEL OF SCRAPIE, Neurodegeneration, 4(2), 1995, pp. 203-207
Citations number
15
Categorie Soggetti
Neurosciences
Journal title
Neurodegeneration → ACNP
ISSN journal
10558330
Volume
4
Issue
2
Year of publication
1995
Pages
203 - 207
Database
ISI
SICI code
1055-8330(1995)4:2<203:MAOTBI>2.0.ZU;2-0
Abstract
Magnetic resonance (MR) imaging in combination with gadolinium-diethyl enetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investi gate the integrity of the blood-brain barrier in a hamster model of sc rapie (263K) during the clinical phase of the disease. The post Gd-DPT A images of the infected hamster brain showed marked enhancement, whic h was not present in control animals. These results that blood-brain b arrier function is disrupted in the clinically-affected animal.