STRUCTURE-ACTIVITY RELATIONSHIP BETWEEN THE HYDROPHOBICITY OF ALKALI-METAL SALTS OF WARFARIN [3-(ALPHA-ACETONYL-BENZYL)-4-HYDROXYCOUMARIN] AND THE EFFECTIVENESS OF THE TASTE RESPONSE TO THESE SALTS IN MICE

The taste responses to five alkali metal salts of warfarin, aqueous ro denticides, in laboratory mice were observed at a short measurement ti me of 20 min by the two-bottle preference test using a licking time mo nitoring system newly developed. It was made clear that the order of t aste avoidance to the warfarin salts was as follows: cesium salt > rub idium salt > lithium salt > sodium salt > potassium salt. The relation ship between the hydrophobicity of the warfarin salts and the effectiv eness of the taste avoidance was analyzed. The effectiveness of the ta ste avoidance largely depended on the hydrophobicity.