MACQUARIMICINS, MICROBIAL METABOLITES FROM MICROMONOSPORA .2. ISOLATION AND STRUCTURAL ELUCIDATION

A novel series of carbocyclic compounds has been isolated from two rel ated Micromonospora cultures. The C-19 and C-22 macquarimicins represe nt different end products on a similar biosynthetic scheme. 1-D and 2- D homonuclear and heteronuclear NMR experiments allowed assignment of the basic structures of the macquarimicins. An X-ray structure of macq uarimicin B suggested the stereochemistry for the series which was not discernible from spectroscopic data alone.