THE MULTIPLE FUNCTIONS OF HEMOGLOBIN

Authors
GIARDINA B MESSANA I SCATENA R CASTAGNOLA M
Citation
B. Giardina et al., THE MULTIPLE FUNCTIONS OF HEMOGLOBIN, Critical reviews in biochemistry and molecular biology, 30(3), 1995, pp. 165-196
Citations number
110
Categorie Soggetti
Biology
Journal title
Critical reviews in biochemistry and molecular biology → ACNP
ISSN journal
10409238
Volume
30
Issue
3
Year of publication
1995
Pages
165 - 196
Database
ISI
SICI code
1040-9238(1995)30:3<165:TMFOH>2.0.ZU;2-S
Abstract
The aim of this review is to focus and discuss several parallel biolog ical functions of hemoglobin besides its basic function of oxygen tran sport. In light of the information present in the literature the follo wing possible physiological roles of hemoglobin are discussed: (1) hem oglobin as molecular heat transducer through its oxygenation-deoxygena tion cycle, (2) hemoglobin as modulator of erythrocyte metabolism, (3) hemoglobin oxidation as an onset of erythrocyte senescence, (4) hemog lobin and its implication in genetic resistance to malaria, (5) enzyma tic activities of hemoglobin and interactions with drugs, and (6) hemo globin as source of physiological active catabolites.