SILVER(I) COMPOUNDS OF SOME SULFONAMIDES

As early as 1942/43 Wruble [1] prepared a number of colloidal silver s ulfonamides and found that these compounds were efficacious as antisep tics and bactericides. In 1968 Fox [2] introduced silver sulfadiazine in topical treatment of burns. Since that time an increase of interest in the metal complexes of sulfonamides has been noticed. Among these, the silver(I) compounds are the most promising ones for the managemen t of burns as evidenced by the introduction to the therapy of silver S ulfadiazine (Flammazine(R), Philips-Dufar, The Netherlands) and silver sulfahiazole (Argosulfan(R), Polfa, Poland). A great deal of effort w as devoted the structure of the silver(I) compounds of sulfonamides by Bult and co-workers [3,4]. Hence, the coordination compounds of silve r(I) with sulfathiazole (SUL), sulfamethoxazole (SUM), amidoxal (AMI), diuramid (DIU) seemed worthy of exploration. The crystal structure an d thermal stability of these compounds were of primary interest.