Cinnamoyl isothiocyanate (1) was utilized in the synthesis of a number
of pyrimidines by the reaction with enaminone 2, aniline or cyano(thi
o)acetamide. Also 1 reacted with ethylcyanoacetate to give an intermed
iate which was then condensed with guanidine, aniline, and/or hydrazin
e hydrate.