Rj. Ward et al., BRAIN IRON IN THE FERROCENE-LOADED RAT - ITS CHELATION AND INFLUENCE ON DOPAMINE METABOLISM, Biochemical pharmacology, 49(12), 1995, pp. 1821-1826
After administration of the ferrocene derivative 3,5,5-trimethyl hexan
oyl ferrocene to rats for 4 weeks various brain regions including subs
tantia nigra, cerebellum and cerebral cortex showed up to 50% increase
in iron content. Subsequent administration of one of the hydroxypyrid
ones CP20, CP24 and CP94, or the siderophore desferrioxamine caused a
significant decrease in the iron content of these various brain region
s. Each of the hydroxypyridones and the siderophore influenced dopamin
e metabolism by causing significant variations in both homovanillic ac
id and dopamine turnover.