AN OPEN MULTICENTER STUDY TO COMPARE THE EFFICACY OF INTRAPERITONEAL INSEMINATION AND INTRAUTERINE INSEMINATION FOLLOWING MULTIPLE FOLLICULAR DEVELOPMENT AS TREATMENT FOR UNEXPLAINED INFERTILITY

Purpose: This multicenter study was carried out to compare the efficac y of intrauterine insemination (IUI) and intraperitoneal insemination (IPI) associated with multiple follicular development as treatment for unexplained infertility. Method: A total of 205 couples completed the trial. Sixty-seven couples underwent treatment with IPI (group A) and 138 couples underwent treatment with IUI (group B). Results: Clinical pregnancy was obtained in 23 couples in group A (pregnancy rate: 34.3 %) and in 36 couples in group B (pregnancy rate: 26.1%). No significan t difference was observed between group A and group B. As for the evol ution of pregnancies and the incidence of twin pregnancies, no signifi cant difference was observed between the two groups. Conclusions: Beca use IUI and IPI allow us to obtain same results and IPI is more invasi ve than IUI, the latter technique can be considered the method of choi ce and IPI should be used when IUI is difficult to perform, as in the presence of a tight cervical canal.