AN ATTEMPT TO SYNTHESIZE PROSTANOID THROMBOXANE A(2) ANTAGONISTS WITHAN ADDITIONAL PROSTACYCLIN LIKE QUALITY

Authors
KLAR U PLETSCH K REHWINKEL H SCHREYER R
Citation
U. Klar et al., AN ATTEMPT TO SYNTHESIZE PROSTANOID THROMBOXANE A(2) ANTAGONISTS WITHAN ADDITIONAL PROSTACYCLIN LIKE QUALITY, Bioorganic & medicinal chemistry letters, 5(12), 1995, pp. 1215-1218
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
12
Year of publication
1995
Pages
1215 - 1218
Database
ISI
SICI code
0960-894X(1995)5:12<1215:AATSPT>2.0.ZU;2-A
Abstract
The preparation and biological characterisation of prostanoid TXA(2)(T P)-antagonists which are modified at position 9 to add a PGI(2)-like q uality is described. Although we obtained highly potent TP-receptor an tagonists, the synthesized compounds do not inhibit the ADP induced pl atelet aggregation and thus do not have any PGI(2)(IP)-mimetic propert ies.