U. Klar et al., AN ATTEMPT TO SYNTHESIZE PROSTANOID THROMBOXANE A(2) ANTAGONISTS WITHAN ADDITIONAL PROSTACYCLIN LIKE QUALITY, Bioorganic & medicinal chemistry letters, 5(12), 1995, pp. 1215-1218
The preparation and biological characterisation of prostanoid TXA(2)(T
P)-antagonists which are modified at position 9 to add a PGI(2)-like q
uality is described. Although we obtained highly potent TP-receptor an
tagonists, the synthesized compounds do not inhibit the ADP induced pl
atelet aggregation and thus do not have any PGI(2)(IP)-mimetic propert
ies.