QUINUCLIDINE-BASED NK1 ANTAGONISTS, THE ROLE OF THE BENZHYDRYL

Authors
SWAIN CJ FONG TM HAWORTH K OWEN SN SEWARD EM STRADER CD
Citation
Cj. Swain et al., QUINUCLIDINE-BASED NK1 ANTAGONISTS, THE ROLE OF THE BENZHYDRYL, Bioorganic & medicinal chemistry letters, 5(12), 1995, pp. 1261-1264
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
12
Year of publication
1995
Pages
1261 - 1264
Database
ISI
SICI code
0960-894X(1995)5:12<1261:QNATRO>2.0.ZU;2-A
Abstract
Initial work on a series of quinuclidine based antagonists suggested t hat only one of the rings of the benzhydryl was involved in receptor b inding. This communication endeavors to test this hypothesis and to id entify which of the phenyl rings interacts with Histidine 197.