SYNTHESIS OF PEPTIDYL ACETALS AS INHIBITORS OF PROLYL ENDOPEPTIDASE

Authors
AUGUSTYNS K BORLOO M BELYAEV A RAJAN P GOOSSENS F HENDRIKS D SCHARPE S HAEMERS A
Citation
K. Augustyns et al., SYNTHESIS OF PEPTIDYL ACETALS AS INHIBITORS OF PROLYL ENDOPEPTIDASE, Bioorganic & medicinal chemistry letters, 5(12), 1995, pp. 1265-1270
Citations number
23
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
12
Year of publication
1995
Pages
1265 - 1270
Database
ISI
SICI code
0960-894X(1995)5:12<1265:SOPAAI>2.0.ZU;2-4
Abstract
Several acyclic and cyclic dipeptidyl acetals were synthesized. Among these, N-[N-benzyloxycarbonyl-(S)-prolyl]-(S)-prolinal dimethyl acetal 8 was shown to be a potent inhibitor of prolyl endopeptidase.