SYNTHESIS AND ANTIVIRAL ACTIVITY OF RIGID ACYCLONUCLEOTIDE ANALOGS

Authors
CASARA PJ ALTENBURGER JM TAYLOR DL TYMS AS KENNY M NAVE JF
Citation
Pj. Casara et al., SYNTHESIS AND ANTIVIRAL ACTIVITY OF RIGID ACYCLONUCLEOTIDE ANALOGS, Bioorganic & medicinal chemistry letters, 5(12), 1995, pp. 1275-1280
Citations number
19
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
12
Year of publication
1995
Pages
1275 - 1280
Database
ISI
SICI code
0960-894X(1995)5:12<1275:SAAAOR>2.0.ZU;2-H
Abstract
The synthesis, anti-HIV-l and anti-herpesvirus activities of new rigid acyclonucleotide analogs are described. -[2-methylidene-3-(phosphonom ethoxy)propyl]guanine 1a exhibits in vitro anti-HIV-1 activity similar to that of the antiviral agent 9-[2-(phosphonomethoxy)ethyl]adenine ( PMEA). Compound la is 9-fold less toxic to human T-lymphoid cells MT-4 than PMEA.