THE PRESENT SAFETY ASSESSMENT OF DEET

Deet is considered to be the best ''all around'' insect repellent ever developed and is the most widely used insect repellent in the world. Since its first use in a consumer product in 1956, billions of applica tions have been made to human skin. Information about the safety of de et comes from the human clinical literature, animal toxicology studies , and poison control centers' experiences with deet. The clinical Lite rature reports the association of deet with neurotoxicity in 14 indivi duals. Three of the cases resulted in death, whereas all of the other patients completely recovered. The exact role of deet in the toxicity reported is difficult to determine from the reports. Recently reported animal safety studies have examined potential neurotoxicity following murtigenerational dosing. Effects on the nervous system were only see n when generalized toxicity was also observed. Thus deet is not a sele ctive neurotoxin. Important information about deet also comes from an investigation into the reports of adverse affects reported to 71 poiso n control centers in the USA. An important conclusion from this study is that there is no evidence that increasing deet concentration has an y effect on the severity of the symptoms reported. The vast majority o f reported cases had either no symptoms or ones that resolved rapidly. In conclusion, a thorough examination of all information available in dicates that the risk of serious adverse effects following the use of deet is extremely low.