A multifamily psychoeducational intervention was carried out in patien
ts with bipolar disorder. The study explored (1) the effects of the in
tervention on the level of expressed emotion (EE) of key relatives; (2
) the validity of EE defined by a 5-min speech sample as a predictor o
f relapse; and (3) the evaluations of the intervention program by pati
ents and key relatives. Four key relatives in the treatment group, com
pared with none in a waiting list control group, changed from high to
low EE levels. The change was clinically but not statistically signifi
cant, perhaps because of the small sample size. Patients whose key rel
atives had low EE levels had a significantly lower number of relapses
and hospital admissions compared with those whose key relatives had hi
gh EE levels. The psychoeducational program was well received by all p
articipants, and there were no dropouts.