SYNTHESIS OF RO-5H-DIBENZO[A,D]CYCLOHEPTEN-5-YL-2'(3'H)-FURANS] AS POTENTIAL CYTOKINE INHIBITORS

A synthesis of novel ro-5H-dibenzo[a,d]cyclohepten-5-yl-2'(3'H)-furans ] is described. The key reaction was formation of the tetrahydrofuran ring by cyclization of the diol 3 or the protected diol 10. These comp ounds were investigated as potential TNF-alpha inhibitors.