A NEW ROUTE TO 5,6-DIARYLPYRIDAZIN-3-ONES BY METALATION AND CROSS-COUPLING OF PYRIDAZINES

Authors
TRECOURT F TURCK A PARIS A QUEGUINER G
Citation
F. Trecourt et al., A NEW ROUTE TO 5,6-DIARYLPYRIDAZIN-3-ONES BY METALATION AND CROSS-COUPLING OF PYRIDAZINES, Journal of heterocyclic chemistry, 32(3), 1995, pp. 1057-1062
Citations number
10
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
3
Year of publication
1995
Pages
1057 - 1062
Database
ISI
SICI code
0022-152X(1995)32:3<1057:ANRT5B>2.0.ZU;2-R
Abstract
Starting from 3,6-dichloropyridazine, a new route is described to anti hypertensive 5,6-diarylpyridazin-3-ones. This pathway comprises the re gioselective metalation followed by a substitution of the trimethylsil yl moeity. The introduction of iodine by another metalation allowed th e cross coupling of arylboronic acids. The 6-methoxy group was then cl eaved to afford the pyridazinones.