ON THE FORMATION OF ESTRONE LACTAM ESTERS OF N,N-BIS(2-CHLOROETHYL)AMINOCINNAMIC ACID ISOMERS, P-N,N-BIS(2-CHLOROETHYL)AMINOPHENYLBUTYRIC ACID AND THEIR ANTITUMOR-ACTIVITY

Authors
CATSOULACOS P PAIRAS G PAPAGEORGIOU A
Citation
P. Catsoulacos et al., ON THE FORMATION OF ESTRONE LACTAM ESTERS OF N,N-BIS(2-CHLOROETHYL)AMINOCINNAMIC ACID ISOMERS, P-N,N-BIS(2-CHLOROETHYL)AMINOPHENYLBUTYRIC ACID AND THEIR ANTITUMOR-ACTIVITY, Journal of heterocyclic chemistry, 32(3), 1995, pp. 1063-1065
Citations number
9
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Journal of heterocyclic chemistry → ACNP
ISSN journal
0022152X
Volume
32
Issue
3
Year of publication
1995
Pages
1063 - 1065
Database
ISI
SICI code
0022-152X(1995)32:3<1063:OTFOEL>2.0.ZU;2-L
Abstract
New estrone-lactam esters, 17 alpha-aza-D-homo en-3-ol-17-one-N,N-bis( 2-chloroethyl)aminocinnamic isomers and p-N,N-bis(2-chloroethyl)aminop henylbutyrate have been synthesized and tested in P388 leukemia in viv o and P388 and L1210 leukemias in vitro. The effect of these compounds on SCE rates and on cell kinetics in cultured human lymphocytes was s tudied also.