INHIBITION OF TUMOR-CELL GROWTH BY A HUMAN B-CELL LINE

An Adenocarcinoma cell line (Breast-M) and an Epstein-Barr virus (EBV) -infected B-cell line (Hairy-BM) were established from breast tumor ti ssue. The Hairy-BM was CD20(+), CD25 (Tac)+ and surface immunoglobulin (sIg)+. Hairy-BM suppressed the in vitro proliferation of Breast-M in a time- and a dose-dependent manner. The suppression was also found i n 5 different human tumor targets showing tumor-Hairy-BM binding, but not; in 2 murine tumor targets showing no significant tumor-Hairy-BM b inding. Lyric activity of Hairy-BM was found only against Breast-M.