PHASE-II STUDY TO EVALUATE THE TOXICITY AND EFFICACY OF CONCURRENT CISPLATIN AND RADIATION-THERAPY IN THE TREATMENT OF PATIENTS WITH LOCALLY ADVANCED SQUAMOUS-CELL CARCINOMA OF THE CERVIX

Sixty patients presenting with poor prognosis squamous cell cancer of the cervix have been studied in a phase II clinical trial, Patients we re treated with radiotherapy and concurrent cisplatin chemotherapy eve ry 10 days. Treatment was well tolerated with all patients completing radiotherapy as prescribed. There was one case of grade 4 acute bowel toxicity, Significant late morbidity was acceptable for this group of patients being restricted to two cases (3.3%) of grade 4 toxicity to t he bowel, Pelvic control rates of 78% have been observed. There have b een no pelvic recurrences after 26 months, although recurrences beyond the pelvis have occurred up to 4 years later, Actuarial 4-year surviv al is encouraging at 60%. (C) 1995 Academic Press, Inc.