PARANEOPLASTIC RETINOPATHY ASSOCIATED WITH UTERINE SARCOMA

We present the first reported case of cancer-associated retinopathy wi th uterine sarcoma. A 65-year-old woman presented in August 1990 with loss of vision, photophobia, and visual field restriction. Antiretinal antibodies were elevated. A diagnosis of cancer-associated retinopath y was made, the patient was started on prednisone, and a workup for ma lignancy was initiated. The patient was found to have uterine sarcoma. She underwent an extrafascial hysterectomy with bilateral salpingo-oo phorectomy followed by eight courses of chemotherapy (carboplatin and cyclophosphamide). After that, the patient's vision improved, her visu al field stabilized. She was doing well when last seen, in July 1994. The literature regarding cancer-associated retinopathy and paraneoplas tic syndromes associated with gynecologic malignancies is reviewed. (C ) Academic Press, Inc.