THE LIGAND EFFECT IN COPPER(I)-CATALYZED CHEMOSELECTIVE AMIDE CARBAMOYLATION IN CABERGOLINE SYNTHESIS

Authors
CANDIANI I CABRI W ZARINI F BEDESCHI A PENCO S
Citation
I. Candiani et al., THE LIGAND EFFECT IN COPPER(I)-CATALYZED CHEMOSELECTIVE AMIDE CARBAMOYLATION IN CABERGOLINE SYNTHESIS, Synlett, (6), 1995, pp. 605-606
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1995
Pages
605 - 606
Database
ISI
SICI code
0936-5214(1995):6<605:TLEICC>2.0.ZU;2-C
Abstract
The effect of phosphorus and nitrogen ligands on the CuCl catalysed re action of ethylisocyanate with an ergoline carboxamide has been studie d. Phosphorus ligands afford chemoselectively the desired compound, wh ile nitrogen ligands revert the observed selectivity. The use of phosp horus and nitrogen ligands is a novel and mild method for the Cu(I) sa lts catalyzed carbamoylation by alkylisocyanates.