THE SYNTHESIS OF PROLINE DERIVED HOMOCHIRAL AMINE OXIDES

Authors
ONEIL IA MILLER ND BARKLEY JV LOW CMR KALINDJIAN SB
Citation
Ia. Oneil et al., THE SYNTHESIS OF PROLINE DERIVED HOMOCHIRAL AMINE OXIDES, Synlett, (6), 1995, pp. 617-618
Citations number
4
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Synlett → ACNP
ISSN journal
09365214
Issue
6
Year of publication
1995
Pages
617 - 618
Database
ISI
SICI code
0936-5214(1995):6<617:TSOPDH>2.0.ZU;2-D
Abstract
The oxidation of a number of N-benzyl proline derivatives is described . The oxidation proceeds with complete diastereoselectivity to give ho mochiral amine oxides when a hydrogen bond donor group is located in t he proline carboxylate side chain. The product amine oxides are highly stable, crystalline compounds. In all eases, the amine oxide is forme d syn to the hydrogen bonding donor group.