IS THE ION-SELECTIVE SURFACE MEASUREMENT ABLE TO DETECT AN ISCHEMIC TYPE INJURY IN THE LIVER - A STUDY IN RAT RIVER TRANSPLANTATION

Summ. Aim of the study is to detect a reperfusion injury in rat liver transplantation by the ion-selective Surface-Measurement (OMS). Method s: Lewis rats served as models for 30 liver transplantations with 1, 6 or 12 hrs of cold ischemia respectively. Directly before, during and after transplantation potassium- and hydrogen-concentrations were meas ured with the OMS and compared to transaminase values on day 1, 3 and 7 as well as to biopsies on day 3. Results: Transaminase values and hi stology show ischemic cell injuries correlating to the lengh of ischem ia, whereas potassium- and hydrogen-concentrations on the organ surfac e do not. Conclusions: Ischemic cell injury in the rat liver cannot be detected by the Ion-selective Measurement.