Ld. Truong et al., A COMPREHENSIVE CHARACTERIZATION OF LYMPHOEPITHELIAL CYST ASSOCIATED WITH THE PANCREAS, The American journal of surgery, 170(1), 1995, pp. 27-32
BACKGROUND: Lymphoepithelial cyst of the pancreas is a rare but distin
ctive cystic lesion lined by a mature, keratinizing squamous epitheliu
m and surrounded by lymphoid tissue, METHODS: TO gain more insights in
to this entity, we describe 5 examples of lymphoepithelial cyst of the
pancreas (2 of which were briefly described before) and compare them
with similar cases in the literature for a total of 19 cases. RESULTS:
The male:female ratio was 16:3; patients' ages ranged from 32 to 73 y
ears (mean and median 51), The lymphoepithelial cyst was incidentally
found at autopsy in 4 patients (21%) or during evaluation for unrelate
d diseases in another 4 patients(21%). In the remaining 11 patients, t
he cyst was associated with abdominal pain in 9 (47% of all patients),
nausea/vomiting in 3 (16%), diarrhea in 1 (5%), and nonspecific syste
mic symptoms in 6 (32%) (some patients had move than 1 associated symp
tom). Computed axial tomography scan, with or without ultrasonographic
study, was done in 16 cases and uniformly displayed a single, well-ci
rcumscribed, cystic mass protruding beyond the surface of the pancreas
; the rest of the pancreas was normal, Intraoperatively, the cyst was
readily apparent once the lesser sac was entered and the surface of th
e pancreas exposed; the cyst was located at the head (3 cases), neck (
1 case), body (6 cases), and tail (9 cases), Surgery was done for all
15 clinical cases and included local excision of the cyst with a thin
rim of attached, underlying pancreas (6 cases), or distal pancreatecto
my with (4 cases) or without (3 cases) splenectomy. Follow-up informat
ion, available in 7 cases, showed that all symptoms disappeared and th
e patients were alive and well up to 6 years after surgery, CONCLUSION
S: This rare cyst of the pancreas has a uniform and characteristic cli
nicopathologic profile, enabling easy and accurate diagnosis, Although
the histogenesis of lymphoepithelial cysts is not known, they are ben
ign and can be cured by local excision.