DIABETES AFFECTS ALPHA-CRYSTALLIN CHAPERONE FUNCTION

Authors
CHERIAN M ABRAHAM EC
Citation
M. Cherian et Ec. Abraham, DIABETES AFFECTS ALPHA-CRYSTALLIN CHAPERONE FUNCTION, Biochemical and biophysical research communications, 212(1), 1995, pp. 184-189
Citations number
19
Categorie Soggetti
Biology,Biophysics
Journal title
Biochemical and biophysical research communications → ACNP
ISSN journal
0006291X
Volume
212
Issue
1
Year of publication
1995
Pages
184 - 189
Database
ISI
SICI code
0006-291X(1995)212:1<184:DAACF>2.0.ZU;2-M
Abstract
rn vitro glycation was previously shown to influence alpha-crystallin chaperone function. In the present study we show that this function is compromised in diabetes. The alpha(H), alpha(L) and the total alpha f ractions were isolated by gel permeation chromatography from the water - soluble protein of streptozotocin - diabetic as well as age-matched normal rats. Based on the beta(L)-crystallin thermal denaturation ass ay the chaperone function was significantly decreased in the diabetic rats. (C) 1995 Academic Press, Inc.