SOLID-STATE PHOTOREACTIVITY OF A DIOXOLENONEMETHYL ESTER

Authors
ALBINI A ALPEGIANI M BORGHI D DELNERO S FASANI E PERRONE E
Citation
A. Albini et al., SOLID-STATE PHOTOREACTIVITY OF A DIOXOLENONEMETHYL ESTER, Tetrahedron letters, 36(26), 1995, pp. 4633-4636
Citations number
17
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
36
Issue
26
Year of publication
1995
Pages
4633 - 4636
Database
ISI
SICI code
0040-4039(1995)36:26<4633:SPOADE>2.0.ZU;2-X
Abstract
The dioxolenonemethyl moiety of the oral penem prodrug FCE 25199 (1) w as found to be a source of photochemical lability in the solid state. Reactions centered on the formation and decomposition of a hydroperoxi de (3) have been observed and rationalized. Expedients have been devis ed to improve the shelf-life of crystalline 1 up to acceptable levels.