Bm. Drachman et al., CORTICAL BLINDNESS SECONDARY TO CYCLOSPORINE AFTER ORTHOTOPIC HEART-TRANSPLANTATION - A CASE-REPORT AND REVIEW OF THE LITERATURE, The Journal of heart and lung transplantation, 15(11), 1996, pp. 1158-1164
Cyclosporine neurotoxicity has been described after liver, kidney, and
bone marrow transplantation and has been associated with a number of
risk factors, including hypomagnesemia and low serum cholesterol level
s. Reports in heart transplant recipients are less common. We present
a patient with cortical blindness secondary to cyclosporine after orth
otopic heart transplantation. The patient had confusion, focal visual
field defects, and bilateral occipital lobe lesions shown on magnetic
resonance imaging. Although he had significant clinical improvement wi
th decreasing cyclosporine levels, residual computerized visual field
defects and magnetic resonance imaging abnormalities were documented s
everal months later.