CORTICAL BLINDNESS SECONDARY TO CYCLOSPORINE AFTER ORTHOTOPIC HEART-TRANSPLANTATION - A CASE-REPORT AND REVIEW OF THE LITERATURE

Citation
Bm. Drachman et al., CORTICAL BLINDNESS SECONDARY TO CYCLOSPORINE AFTER ORTHOTOPIC HEART-TRANSPLANTATION - A CASE-REPORT AND REVIEW OF THE LITERATURE, The Journal of heart and lung transplantation, 15(11), 1996, pp. 1158-1164
Citations number
38
Categorie Soggetti
Cardiac & Cardiovascular System",Transplantation
ISSN journal
10532498
Volume
15
Issue
11
Year of publication
1996
Pages
1158 - 1164
Database
ISI
SICI code
1053-2498(1996)15:11<1158:CBSTCA>2.0.ZU;2-3
Abstract
Cyclosporine neurotoxicity has been described after liver, kidney, and bone marrow transplantation and has been associated with a number of risk factors, including hypomagnesemia and low serum cholesterol level s. Reports in heart transplant recipients are less common. We present a patient with cortical blindness secondary to cyclosporine after orth otopic heart transplantation. The patient had confusion, focal visual field defects, and bilateral occipital lobe lesions shown on magnetic resonance imaging. Although he had significant clinical improvement wi th decreasing cyclosporine levels, residual computerized visual field defects and magnetic resonance imaging abnormalities were documented s everal months later.