BIOCHEMICAL ASPECTS OF TOXIC EFFECTS OF S UPERMETHRIN IN THE CONDITIONS OF CHRONIC 140-DAY AVIAN REPRODUCTIVE TEST

Chronic toxic effects of supermethrin on some biochemical parameters ( AST, ALT, LDH, creatinine and total proteins) were investigated in 84 individuals of Japanese quail divided into four groups (control - K, e xperimental group I - P1, experimental group II - P2, experimental gro up III - P3) in the conditions of 140-day avian reproductive test. The three experimental groups received the tested substance at these dose s: P1 - 10.7 mg/kg 1.w./day, P2 - 21.4 mg/kg 1.w./day, P3 - 35.7 mg/kg 1.w./day. The results of observation of the enzyme activities AST and ALT show that only the AST activity (in the course of 140-day avian r eproductive test) significantly increased to 1.225 mu kat/l in the fem ales of experimental group P1, to 1.053 mu kat/l in P2 and to 1.014 mu kat/l in P3 against the control, in which the AST activity was 0.670 mu kat/l. The values of AST activity in the males were 1.143 mu kat/l in P1, 1.117 mu kat/l in P2 and 1.090 mu kat/l in P3 against the contr ol 0.8395 mu kat/l. The investigation of variations in total LDH activ ity in Japanese quail after 140-day avian reproductive test has shown an increase in the LDH activity in the males (11.193 mu kat/l in P1, 1 1.269 mu kat/l in P2, 8.245 mu kat/l in P3 and 7.362 mu kat/l in K) as well as in the females (10.91 mu kat/l in P1, 12.023 mu kat/l in P2, 10.196 mu kat/l in P3 and 7.055 mu kat/l in K). It can be concluded on the basis of our biochemical results that supermethrin is a pesticide of organic origin that will not affect the above biochemical paramete rs in wild gallinaceous fowl, especially if the amount and concentrati on (0.1-0.2 1 of 15% solution per ha) applied in farming practice are taken into account.