LOCALIZATION OF THE HUMAN STEM-CELL TYROSINE KINASE-1 GENE (FLT3) TO 13Q12-]Q13

We have previously reported the cloning of stem cell tyrosine kinase-l (STK-1, gene symbol FLT3), the human homolog of the mouse Flk2/Flt3 g ene (Small et al., 1994). This growth factor receptor is expressed in CD34(+) human bone marrow (stem/progenitor) cells. We have mapped the gene for STK-1 using PCR screening of a human-rodent somatic cell hybr id panel, and fluorescence in situ molecular hybridization (FISH) of S TK-1 genomic probes to mitotic chromosomes of normal human lymphocytes . The results of both analyses show that the gene for STK-1 (FLT3) loc alizes to chromosome 13q12-->q13.