Objective. To describe the clinical characteristics of soft tissue tub
erculosis (TB). Methods. Retrospective review of all cases of soft tis
sue TB seen by the authors. Results. Eleven cases were seen between 19
88 and 1994. All patients but one were foreign born. Six patients had
collagen vascular disorders and another had a kidney transplant. Five
were taking immunosuppressive therapy and/or prednisone. Three had pre
ceding trauma to the affected area. Five had evidence of previous TB b
y history or chest radiograph. Symptoms (mean duration 4.4 months) inc
luded swelling and pain and often mimicked the underlying disease. Six
patients had definite or suspected active TB at other sites. Good ini
tial responses were seen with debridement or drainage and multiple dru
gs for 6 to 12 months. Two patients have had possible relapses at othe
r sites. Medication intolerance was frequent. Conclusion. TB should be
considered in patients who present with unexplained soft tissue swell
ing and pain, particularly if they are immunosuppressed, were foreign
born in an endemic area, have an abnormal chest radiograph, or have ha
d trauma to the affected area.