CROSS-RESISTANCE TO POLYENE AND AZOLE DRUGS IN CRYPTOCOCCUS-NEOFORMANS

Citation
T. Josephhorne et al., CROSS-RESISTANCE TO POLYENE AND AZOLE DRUGS IN CRYPTOCOCCUS-NEOFORMANS, Antimicrobial agents and chemotherapy, 39(7), 1995, pp. 1526-1529
Citations number
21
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
ISSN journal
00664804
Volume
39
Issue
7
Year of publication
1995
Pages
1526 - 1529
Database
ISI
SICI code
0066-4804(1995)39:7<1526:CTPAAD>2.0.ZU;2-E
Abstract
Fluconazole was observed to inhibit sterol 14 alpha-demethylase in the human pathogen Cryptococcus neoformans, and accumulation of a ketoste roid product was associated with growth arrest. A novel mechanism(s) o f azole and amphotericin B cross-resistance was identified, unrelated to changes in sterol biosynthesis, as previously identified in Sacchar omyces cerevisiae, Reduced cellular content of drug could account for the resistance phenotype, indicating the possible involvement of a mec hanism similar to multidrug resistance observed in higher eukaryotes.