IN-VITRO ACTIVITY OF THE SEMISYNTHETIC GLYCOPEPTIDE AMIDE MDL-63,246

The in vitro activity of the semisynthetic glycopeptide amide MDL 63,2 46 against 293 U.S. clinical isolates of gram-positive cocci was deter mined by the broth microdilution method. When compared with teicoplani n, MDL 63,246 had improved activity against Staphylococcus epidermidis (MICs that inhibited 90% strains tested [MIC(90)s], 0.25 versus 8 mu g/ml, respectively), Staphylococcus haemolyticus (MIC(90)s, 1 versus 3 2 mu g/ml, respectively), and VanA Enterococcus faecium (MIC(90)s, 32 versus greater than or equal to 1,024 mu g/ml, respectively).