ANALYSIS OF MUTATIONS AT POSITION-184 IN REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1

Authors
BOYER PL HUGHES SH
Citation
Pl. Boyer et Sh. Hughes, ANALYSIS OF MUTATIONS AT POSITION-184 IN REVERSE-TRANSCRIPTASE OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1, Antimicrobial agents and chemotherapy, 39(7), 1995, pp. 1624-1628
Citations number
42
Categorie Soggetti
Pharmacology & Pharmacy",Microbiology
Journal title
Antimicrobial agents and chemotherapy → ACNP
ISSN journal
00664804
Volume
39
Issue
7
Year of publication
1995
Pages
1624 - 1628
Database
ISI
SICI code
0066-4804(1995)39:7<1624:AOMAPI>2.0.ZU;2-5
Abstract
We have analyzed recombinant human immunodeficiency virus type I rever se transcriptases that contain mutations at position 184. These varian ts retain high levels of RNA-dependent DNA polymerase activity and sho w resistance to ddITP. However, the mutants varied in their ability to polymerize processively. The variants Met184Ile and Met184Val showed slight reductions in processivity relative to that of the wild-type en zyme; the variants Metl84Ala and Met184Leu showed considerable reducti ons in their processivity.