LONG-RANGE STRATEGIES IN THE LHASA PROGRAM - THE QUINONE DIELS-ALDER TRANSFORM

Authors
OTT MA NOORDIK JH
Citation
Ma. Ott et Jh. Noordik, LONG-RANGE STRATEGIES IN THE LHASA PROGRAM - THE QUINONE DIELS-ALDER TRANSFORM, Journal of chemical information and computer sciences, 37(1), 1997, pp. 98-108
Citations number
65
Categorie Soggetti
Information Science & Library Science","Computer Application, Chemistry & Engineering","Computer Science Interdisciplinary Applications",Chemistry,"Computer Science Information Systems
Journal title
Journal of chemical information and computer sciences → ACNP
ISSN journal
00952338
Volume
37
Issue
1
Year of publication
1997
Pages
98 - 108
Database
ISI
SICI code
0095-2338(1997)37:1<98:LSITLP>2.0.ZU;2-N
Abstract
The quinone Diels-Alder (QDA) reaction has considerable synthetic powe r in terms of introducing structural complexity. As a consequence, the corresponding transform is a worthwhile goal in retrosynthetic analys is and therefore has been implemented as a transform-goal, or long-ran ge, strategy in the LHASA program. The implemented strategy allows LHA SA to convert any suitable target containing the decalin ring system i nto a tetrahydronaphthoquinone to which the QDA transform can be direc tly applied. Illustrative examples of retrosynthetic sequences produce d by the long-range transform are given.