THA - HISTORICAL ASPECTS, REVIEW OF PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFECTS

The authors reviewed historical data in the development of THA, as wel l as recent data on its pharmacological properties and therapeutic eff ects on cognitive dysfunction. A medline search was conducted to ident ify the trials conducted with THA in Alzheimer's disease (AD) patients . The findings seem to lend support to some palliative action of THA, especially at higher doses, but in these doses about 2/3 of the patien ts experience significant adverse reactions. The significance of these findings is discussed, with emphasis on the their relevance for the m anagement of AD patients.