STEREOCHEMISTRY AND CONFORMATION OF DOLABELLANE DITERPENES - AN NMR AND MOLECULAR MECHANICS STUDY

The preferred conformations in solution of five dolabellane diterpenes [4-8] previously isolated from marine organisms have been determined on the basis of a complete H-1- and C-13-nmr analysis, including NOESY and lanthanide-induced shift experiments, in combination with MM2 cal culations. This study led also to a revision of the stereochemistry fo r three of these dolabellanes.