TYROSINASE INHIBITORS FROM BOLIVIAN MEDICINAL-PLANTS

Authors
KUBO I YOKOKAWA Y KINSTHORI I
Citation
I. Kubo et al., TYROSINASE INHIBITORS FROM BOLIVIAN MEDICINAL-PLANTS, Journal of natural products, 58(5), 1995, pp. 739-743
Citations number
28
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
5
Year of publication
1995
Pages
739 - 743
Database
ISI
SICI code
0163-3864(1995)58:5<739:TIFBM>2.0.ZU;2-Z
Abstract
Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.1 4.18.1) activity, afforded six inhibitors from three Bolivian medicina l plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, i nhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) mediat ed by a mushroom tyrosinase.