SIMULTANEOUS DETERMINATION OF ARTEMISININ AND ITS BIOPRECURSORS IN ARTEMISIA-ANNUA

Authors
VANDENBERGHE DR VERGAUWE AN VANMONTAGU M VANDENEECKHOUT EG
Citation
Dr. Vandenberghe et al., SIMULTANEOUS DETERMINATION OF ARTEMISININ AND ITS BIOPRECURSORS IN ARTEMISIA-ANNUA, Journal of natural products, 58(5), 1995, pp. 798-803
Citations number
29
Categorie Soggetti
Chemistry,"Plant Sciences","Pharmacology & Pharmacy
Journal title
Journal of natural products → ACNP
ISSN journal
01633864
Volume
58
Issue
5
Year of publication
1995
Pages
798 - 803
Database
ISI
SICI code
0163-3864(1995)58:5<798:SDOAAI>2.0.ZU;2-Y
Abstract
Artemisia annua has been used for the treatment of fever and malaria. Artemisinin [1], a sesquiterpene lactone constituent of this plane, is responsible for its therapeutic effects. A rapid, sensitive, and spec ific reversed-phase hplc method using electrochemical and uv detection has been developed for the simultaneous determination in plant extrac ts of 1 and its bioprecursors artemisinic acid [2], arteannuin B [3], and artemisitene [4].