During Schistosoma mansoni infection, there is morphological evidence
of involvement of various hematopoietic growth factors, which cause eo
sinophil, neutrophil, megakaryocytic and erythroid extramedullary foci
in the liver lymph nodes and omental and mesenteric milky spots. Whil
e the eosinophil metaplasia in the periphery of hepatic granulomas rou
ghly reproduced the intensity of the medullary eosinopoiesis, the neut
rophil metaplasia, on the contrary, was more intense during the period
of neutrophil depression in the bone mal row. This fact suggests that
extramedullary, hematopoietic foci are locally regulated, and amplify
and/or compensate the systemic hematopoietic response during the infe
ction.