PARTIAL OR NEAR-TOTAL PANCREATECTOMY FOR NESIDIOBLASTOSIS

Citation
K. Parashar et al., PARTIAL OR NEAR-TOTAL PANCREATECTOMY FOR NESIDIOBLASTOSIS, European journal of pediatric surgery, 5(3), 1995, pp. 146-148
Citations number
21
Categorie Soggetti
Surgery,Pediatrics
ISSN journal
09397248
Volume
5
Issue
3
Year of publication
1995
Pages
146 - 148
Database
ISI
SICI code
0939-7248(1995)5:3<146:PONPFN>2.0.ZU;2-J
Abstract
We report on 11 consecutive cases of nesidioblastosis successfully man aged, in a 22-year period from 1972-1993 at The Children's Hospital, B irmingham, England. In the pre-operative period all patients were mana ged by constant glucose administration (> 10 mg/kg/min) and hyperglyca emic agents such as diazoxide, glucagon, growth hormone and somatostat in either singly or in combination. Seven patients underwent partial p ancreatectomy, 2 of whom needed a subsequent near-total resection; 4 o thers had a near-total pancreatectomy as the primary procedure. The 5 patients who have had partial pancreatectomies are healthy and on no r egular medication. Of the 6 patients who had near-total pancreatectomy 3 require insulin for diabetes mellitus and 3 are on pancreatin for p ancreatic exocrine deficiency. We recommend partial pancreatectomy as the first operation in the treatment of nesidioblastosis.