We report on 11 consecutive cases of nesidioblastosis successfully man
aged, in a 22-year period from 1972-1993 at The Children's Hospital, B
irmingham, England. In the pre-operative period all patients were mana
ged by constant glucose administration (> 10 mg/kg/min) and hyperglyca
emic agents such as diazoxide, glucagon, growth hormone and somatostat
in either singly or in combination. Seven patients underwent partial p
ancreatectomy, 2 of whom needed a subsequent near-total resection; 4 o
thers had a near-total pancreatectomy as the primary procedure. The 5
patients who have had partial pancreatectomies are healthy and on no r
egular medication. Of the 6 patients who had near-total pancreatectomy
3 require insulin for diabetes mellitus and 3 are on pancreatin for p
ancreatic exocrine deficiency. We recommend partial pancreatectomy as
the first operation in the treatment of nesidioblastosis.