Entamoeba histolytica and Giardia lamblia constitute, in a world conte
xt, the two commonest intestinal protozoan parasites to affect man. Th
erefore accurate diagnosis is of paramount importance if resultant inf
ections ore to be adequately managed. Demonstration of the cyst or tro
phozoite stage in a faecal sample(s) (several newer techniques are ava
ilable) remains the lynch-pin of diagnostic strategies; however, excre
tion of cysts, especially, is intermittent and evidence of infection i
s not always manifest in a single examination. A limited range of othe
r techniques is also available for a 'parasitological diagnosis'. With
in the last decade, serological techniques (largely dependent on invas
ive properties of the organism) have attained levels of diagnostic com
petence. Therefore, a very high index of suspicion now ensues from ind
irect evidence of infection.