A CONCISE SYNTHETIC ROUTE TO PURE ISOMERS OF THE ANTIFUNGAL AGENTS (E)-1,2-DIARYL-3-(1-IMIDAZOLYL)-1-PROPENES AND (Z)-1,2-DIARYL-3-(1-IMIDAZOLYL)-1-PROPENES

An efficient and relatively simple synthetic sequence is detailed for the preparation of 1,2-diaryl-3-(1-imidazolyl)-1-propenes 4, a class o f biologically active compounds. The method gives access to pure geome trical isomers. Spectral characteristics, which enable the distinction between E and Z isomers, are discussed.