THE PHARMACOKINETICS OF BUPIVACAINE FOLLOWING INTERPLEURAL NERVE BLOCK IN INFANTS OF VERY-LOW-BIRTH-WEIGHT

Authors
WESTON PJ BOURCHIER D
Citation
Pj. Weston et D. Bourchier, THE PHARMACOKINETICS OF BUPIVACAINE FOLLOWING INTERPLEURAL NERVE BLOCK IN INFANTS OF VERY-LOW-BIRTH-WEIGHT, Paediatric anaesthesia, 5(4), 1995, pp. 219-222
Citations number
7
Categorie Soggetti
Anesthesiology,Pediatrics
Journal title
Paediatric anaesthesia → ACNP
ISSN journal
11555645
Volume
5
Issue
4
Year of publication
1995
Pages
219 - 222
Database
ISI
SICI code
1155-5645(1995)5:4<219:TPOBFI>2.0.ZU;2-0
Abstract
Infants of very low birthweight (VLBW) who underwent thoracotomy were given 2.0 mg . kg(-1) of bupivacaine by the intrapleural route, and se rial blood levels were taken to determine the pharmacokinetic profile in this group of babies. It was apparent that the half life was longer , clearance lower, and volume of distribution greater than in term inf ants. Although the drug did not reach toxic levels at this dose, cauti on should be observed when redosing as the accumulation of the drug ma y be unpredictable.