EXACERBATION OF MYASTHENIA-GRAVIS BY PEFL OXACIN

Pefloxacine 800 mg single dose was given as routine treatment after a cystomanometric examination of a 45-year-old woman with a 30-month his tory of generalized myasthenia gravis. One hour after, the patient dev eloped exacerbation of myasthemia gravis with bilateral ptosis and an increased generalized weakness. She experienced a rapid improvement du ring the next 8 hours and physical examination returned to normal with in one day. No additional factors which migh have contributed to the e xacerbation of myasthenia gravis were found. The report of exacerbatio n of myasthenia gravis with other antibiotic belonging to the group of fluoroquinolones (ciproflaxacin, norfloxacin and ofloxacin) prompt us to recommend caution with the use of all fluoroquinolones in myasteni c patients.