PROGNOSTIC FACTORS AND TREATMENT RESULTS FOR SUPRATENTORIAL PRIMITIVENEUROECTODERMAL TUMORS IN CHILDREN USING RADIATION AND CHEMOTHERAPY -A CHILDRENS CANCER GROUP RANDOMIZED TRIAL

Purpose: To determine clinical characteristics and response to treatme nt for children with supratentorial primitive neuroectodermal tumors ( S-PNETs). Patients and Methods: After surgery and staging, 55 patients aged 1.5 to 19.3 years with S-PNETs were randomized to receive cranio spinal radiotherapy (RT) followed by eight cycles of 1-(2-chloro-ethyl )-3-cyclohexylnitrosourea (CCNU), vincristine (VCR), and prednisone (s tandard treatment) or two cycles of 8-in-1 chemotherapy followed by RT and then eight additional cycles of 8-in-1. Results: Three-year Kapla n-Meier estimates (estimate +/- SE) of survival and progression-free s urvival (PFS) rates for patients with confirmed diagnoses of S-PNET we re 57% +/- 8% and 45% +/- 8%, respectively; survival and PFS rates for children with PNETs located in the pineal region were 73% +/- 12% and 61% +/- 13%, respectively, and were significantly different from the other S-PNETs (P < .03). The 8-in-1 arm had greater toxicity than the standard-treatment arm. Distributions of PFS between the two treatment groups were not significantly different (P > .5). Other univariate pr ognostic factors that influenced PFS included metastasis (M) stage (P < .03: M(0) 50% +/- 9% v M(1-4) 0%) and age (P < .02: 1.5 to 2 years 2 5% +/- 13% v greater than or equal to 3 years 53% +/- 9%). Conclusion: In this first randomized treatment trial for S-PNETs in children, no significant differences were detected between the two treatment groups . M(0) and pineal site of involvement were independent predictors of a better outcome. However, survival was better than previously reported . (C) 1995 by American Society of Clinical Oncology.