INDUCIBLE NITRIC-OXIDE SYNTHASE AND ITS PRODUCT NITRIC-OXIDE, A SMALL-MOLECULE WITH COMPLEX BIOLOGICAL-ACTIVITIES

Authors
KRONCKE KD FEHSEL K KOLBBACHOFEN V
Citation
Kd. Kroncke et al., INDUCIBLE NITRIC-OXIDE SYNTHASE AND ITS PRODUCT NITRIC-OXIDE, A SMALL-MOLECULE WITH COMPLEX BIOLOGICAL-ACTIVITIES, Biological chemistry Hoppe-Seyler, 376(6), 1995, pp. 327-343
Citations number
262
Categorie Soggetti
Biology
Journal title
Biological chemistry Hoppe-Seyler → ACNP
ISSN journal
01773593
Volume
376
Issue
6
Year of publication
1995
Pages
327 - 343
Database
ISI
SICI code
0177-3593(1995)376:6<327:INSAIP>2.0.ZU;2-1
Abstract
More and more attention is paid to the radical nitric oxide which is n ow known to be part of the mammalian physiology and immune system. Nit ric oxide is synthesized by one of the most complicated and fascinatin g enzyme families identified so far. Inducible nitric oxide synthesis after appropriate stimuli has regulatory, cytostatic and/or toxic cons equences and may play an important role in the pathophysiology of seve ral diseases.