SYNTHESIS AND EVALUATION AS A GENE-TRANSFER AGENT OF A 1,2-DIMYRISTOYL-SN-GLYCERO-3-PENTALYSINE SALT

Authors
WEIBEL JM KICHLER A REMY JS GAIDDON C LOEFFLER JP DUPORTAIL G HEISSLER D
Citation
Jm. Weibel et al., SYNTHESIS AND EVALUATION AS A GENE-TRANSFER AGENT OF A 1,2-DIMYRISTOYL-SN-GLYCERO-3-PENTALYSINE SALT, Chemistry Letters, (6), 1995, pp. 473-474
Citations number
9
Categorie Soggetti
Chemistry
Journal title
Chemistry Letters → ACNP
ISSN journal
03667022
Issue
6
Year of publication
1995
Pages
473 - 474
Database
ISI
SICI code
0366-7022(1995):6<473:SAEAAG>2.0.ZU;2-G
Abstract
1,2-Dimyristoyl-sn-glycero-3-pentalysine hexakis(trifluoroacetate) 1 h as been synthesized and its transfection efficiency has been compared with that of the commercially available lipid DOTAP (3T3 mouse fibrobl ast cells; CMV-Luc plasmid). When the positive (lipid)/negative (DNA) charge ratio was 6, the lipid 1 was 1.7 times more efficient than DOTA P.