Jm. Weibel et al., SYNTHESIS AND EVALUATION AS A GENE-TRANSFER AGENT OF A 1,2-DIMYRISTOYL-SN-GLYCERO-3-PENTALYSINE SALT, Chemistry Letters, (6), 1995, pp. 473-474
1,2-Dimyristoyl-sn-glycero-3-pentalysine hexakis(trifluoroacetate) 1 h
as been synthesized and its transfection efficiency has been compared
with that of the commercially available lipid DOTAP (3T3 mouse fibrobl
ast cells; CMV-Luc plasmid). When the positive (lipid)/negative (DNA)
charge ratio was 6, the lipid 1 was 1.7 times more efficient than DOTA
P.