J. Jakobsson et K. Rane, ANESTHESIA FOR SHORT OUTPATIENT PROCEDURES - A COMPARISON BETWEEN THIOPENTONE AND PROPOFOL IN COMBINATION WITH FENTANYL OR ALFENTANIL, Acta anaesthesiologica Scandinavica, 39(4), 1995, pp. 503-507
We studied supplementation of propofol or thiopentone anaesthesia with
0.5 or 1.0 mg alfentanil or 0.05 or 0.1 mg fentanyl for minor gynaeco
logical outpatient procedures. Four hundred patients scheduled for ele
ctive termination of pregnancy were randomly allocated to one of eight
groups. Induction agent doses, peroperative complications, complaints
about pain and emesis during the postoperative period, and time to di
scharge were studied. Propofol compared to thiopentone was associated
with a shorter time to discharge, 103+/-28 and 115+/-33 minutes respec
tively (P<0.05) and anxiety during recovery was more frequent in the t
hiopentone group (P<0.05). The need for postoperative reserve analgesi
cs was less in the alfentanil group (P<0.05). We found, however, no ma
jor differences between the supplementations tested regarding the tota
l dose of induction agent, emesis or time to discharge. Supplementatio
n with 1.0 mg of alfentanil to propofol was found to be the best combi
nation tested for short outpatient procedures.