EFFECTS ON RENAL HEMODYNAMICS AND TUBULAR FUNCTION OF THE CONTRAST-MEDIUM IOXAGLATE IN RENAL-TRANSPLANT PATIENTS

The aim of this study was to evaluate the effects of Ioxaglate on rena l haemodynamics and tubular function in renal transplant patients at i ncreased risk of nephrotoxicity. 21 patients undergoing either intrave nous pyelography or arteriography with Ioxaglate were studied. Renal c learance studies were carried out 1 day before and 1 day after adminis tration of Ioxaglate (173 +/- 37 ml) injected into each patient. None experienced any adverse reaction. Mean serum creatinine, glomerular fi ltration rate (GFR), effective renal plasma flow (ERPF) and urinary NA G excretion were unaltered by ioxaglate. No patient suffered a nephrot oxic reaction or acute oliguria that required dialysis as a result of the administration of contrast material. In the subset of seven patien ts receiving cyclosporine the same results were observed. In the subse t of 10 patients with a GFR lower than 60 ml/min before injection of I oxaglate we also observed no significant change in mean GFR, ERPF and urinary NAG excretion. Only two patients had a transient decrease of G FR of between 10 and 20%. The results of this study show that the ioni c, low osmolar contrast medium ioxaglate may be used safely in patient s with a renal transplant thus extending previous data obtained in pat ients with chronic renal failure.