THE SAR OF -2-PROPYL-3-[(2'-TETRAZOL-5-YL)BIPHEN-4-YL)METHYL] QUINAZOLINONES AS BALANCED AFFINITY ANTAGONISTS OF THE HUMAN AT(1) AND AT(2) RECEPTORS

Authors
DELASZLO SE CHANG RS CHEN TB FAUST KA GREENLEE WJ KIVLIGHN SD LOTTI VJ OMALLEY SS SCHORN TW SIEGL PK TRAN J ZINGARO GJ
Citation
Se. Delaszlo et al., THE SAR OF -2-PROPYL-3-[(2'-TETRAZOL-5-YL)BIPHEN-4-YL)METHYL] QUINAZOLINONES AS BALANCED AFFINITY ANTAGONISTS OF THE HUMAN AT(1) AND AT(2) RECEPTORS, Bioorganic & medicinal chemistry letters, 5(13), 1995, pp. 1359-1364
Citations number
8
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
5
Issue
13
Year of publication
1995
Pages
1359 - 1364
Database
ISI
SICI code
0960-894X(1995)5:13<1359:TSO-Q>2.0.ZU;2-F
Abstract
Modification of the 6-N-alkyl-N-acyl groups of L-159,689, 2-propyl-3-[ (2'-(tetrazol-5-yl)biphen-4-yl)methyl] led to the identification of th e 6-(N-benzoyl-N-(3-pyridylmethyl)) analog(L-162,537). L-162,537 had i mproved aqueous solubility and oral bioavailability in the dog. The SA R of this class of AT(1) and AT(2) Ligands is discussed.